EuroNetHTA published rapid assessment of antibacterial-coated sutures in comparison with non-antibacterial coated sutures in relation to effectiveness and safety for the prevention of superficial and deep incisional surgical site infection in abdominal surgery in adults.
For this purpose, systematic literature review was performed with further meta-analysis. Seven randomized clinical trials (RCTs) were included into analysis of efficacy with total number of randomized patients n=3,580 patients where 52.4% of patients were treated with triclosan-coated sutures and 47.6% were non-antibacterial coated sutures. No published clinical studies on chlorhexidine-coated sutures have been identified. For safety analysis additional seven non-randomized studies were included.
A statistically significant benefit of triclosan-coated sutures in reducing the risk of total incisional surgical site infection was demonstrated in accordance to results of meta-analysis, based on moderate quality RCTs data.
The relative safety of triclosan-coated sutures could not be confirmed due to a lack of reporting of adverse effects in RCTs and non-randomized studied included into assessment.
Full report can be seen here.
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